Cryptic intronic transcriptional initiation generates efficient endogenous mRNA templates for C9orf72-associated RAN translation

Proceedings of the National Academy of Sciences, Volume 122, Issue 32, August 2025. <br/>SignificanceAn intronic GGGGCC repeat expansion inC9orf72supports an unusual translational initiation process known as repeat-associated non-AUG (RAN) translation to produce toxic dipeptide repeat (DPR) proteins that contribute to neurodegeneration in …