Crystal structure and catalytic mechanism of drimenol synthase, an unusual bifunctional terpene cyclase–phosphatase

Proceedings of the National Academy of Sciences, Volume 122, Issue 26, July 2025. <br/>SignificanceTerpenoid natural products have featured prominently in the pharmacopoeia since times of antiquity. For example, C15sesquiterpenes are responsible for the analgesic effects of myrrh, historically prescribed as a painkiller in the Ebers …