Cystathionine γ-lyase is a major regulator of cognitive function through neurotrophin signaling and neurogenesis

Proceedings of the National Academy of Sciences, Volume 122, Issue 52, December 2025. <br/>SignificanceOnce considered to function predominantly in the peripheral systems, cystathionine γ-lyase (CSE) is emerging as a key player in neuroprotection. Prior studies had considered cystathionine β-synthase (CBS) to be the principal enzyme governing H…