Cytosolic proliferating cell nuclear antigen (PCNA) orchestrates neutrophil hyperactivation in COVID-19

Proceedings of the National Academy of Sciences, Volume 122, Issue 43, October 2025. <br/>SignificanceSevere COVID-19 is marked by excessive neutrophil activation, leading to the release of damaging molecules that injure the lungs and other organs. While neutrophil hyperactivation is a hallmark of severe disease, the molecular mechanisms that …