Selective targeting of NRF2-high pancreatic ductal adenocarcinoma with an NQO1-activatable prodrug

Proceedings of the National Academy of Sciences, Volume 123, Number 4, January 2026.
Significance Activation of NRF2 is associated with resistance to oxidant-producing chemotherapies and radiotherapies, as well as increased growth of pancreatic ductal adenocarcinoma (PDAC), metastatic spread, and poor patient survival. Here we show that NRF2highPDAC…