De novo design of protein binders to stabilize monomeric TDP-43 and inhibit its pathological aggregation

Proceedings of the National Academy of Sciences, Volume 122, Issue 36, September 2025. <br/>SignificancePathological aggregation of TDP-43, predominantly driven by its low-complexity domain, is a central driver of many neurodegenerative diseases, including amyotrophic lateral sclerosis and frontotemporal lobar degeneration, yet no effective …