De novo discovery of bicyclic cysteine-rich peptides targeting gasdermin D

Proceedings of the National Academy of Sciences, Volume 123, Number 3, January 2026.
ImportancePyroptosis is a form of programmed dysregulation of cell death that is associated with autoimmune diseases, neurodegenerative diseases and cancer. Gasdermin D (GSDMD) is the main executor of pyroptosis which has become a major problem…