Decreased mitochondrial activity in the demyelinating cerebellum of progressive multiple sclerosis and chronic EAE contributes to Purkinje cell loss

Proceedings of the National Academy of Sciences, volume 122, number 25, June 2025.
Significant dysfunction of multiple sclerosis (MS) contributes to motor impairment, but the underlying mechanisms remain vague. This study shows that the mitochondrial dysfunction, linked to inflammatory demyelination, plays a criticism …