DeepDegradome: A structure-aware deep learning framework for PROTAC and ligand generation against protein targets

Proceedings of the National Academy of Sciences, Volume 123, Number 11, March 2026.
ImportanceTargeted protein degradation, particularly using PROTACs, offers a promising strategy to treat diseases. However, designing effective PROTACs remains challenging due to the limitations of current computational methods. We present DeepDegradome, …