Dibromocarbene addition to bicyclo[1.1.0]butanes: A facile route to substituted bicyclo[1.1.1]pentanes
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Proceedings of the National Academy of Sciences, Volume 122, Number 44, November 2025.
ImportanceBicyclo[1.1.1]pentanes (BCP) have emerged as powerful bioisosteres to enhance the medicinal properties of benzene rings in drug design. Here we report a direct and efficient synthesis of 2,2-dibrominated BCP, which offers a versatile solution…
