Hypoxia inducible factors regulate pneumovirus replication by enhancing innate immune sensing

Proceedings of the National Academy of Sciences, Volume 123, Issue 15, April 2026. <br/>SignificanceThis study explores the role of the hypoxic inducible factor (HIF) signaling pathway in limiting pneumoviral infections, such as respiratory syncytial virus (hRSV) and pneumonia virus of mice (PVM). Using daprodustat, a clinically approved …