Differential O-glucose elongation on a specific EGF repeat within the canonical ligand–binding domain regulates DLL1/4-NOTCH1 signaling

Proceedings of the National Academy of Sciences, Volume 122, Issue 43, October 2025. <br/>SignificanceNotch, a signaling receptor critical for development, differentiation, and homeostasis in multicellular organisms, undergoes multiple posttranslational glycan modifications to regulate its function. WhileO-glucose glycan elongation by xylose …