Distinct transcription factor interactions drive HOXB13 activity in different stages of prostate cancer

Proceedings of the National Academy of Sciences, Volume 122, Issue 49, December 2025. <br/>SignificanceHOXB13 is a lineage-specific transcription factor essential for prostate cancer (PCa) proliferation in both androgen receptor (AR)-positive and AR-negative tumors, with minimal effects on nonprostatic tissues. In AR-negative, stem-like PCa, …