DNA methylation shapes transcription factor binding beyond canonical CpG contexts

Proceedings of the National Academy of Sciences, Volume 122, Issue 51, December 2025. <br/>SignificanceAlthough DNA methylation has long been recognized as an epigenetic regulator, the functional impact of methylation beyond CpG sites—particularly non-CpG and hemimethylation—remains poorly understood. Using a high-throughput, cell-free binding …