Dopamine D1 and D2 receptors differentially control strength and dynamics of abstract decision codes in the primate prefrontal cortex

Proceedings of the National Academy of Sciences, Volume 123, Number 15, April 2026.
Significance How dopamine shapes abstract decision-making in the prefrontal cortex remains a central unresolved problem in neuroscience. Using receptor-specific causal manipulations combined with recordings from single neurons in behavioral primates, we show that…