Drospondin, a glial glycoprotein with similarities to human Reelin/F-spondin, contributes to Drosophila brain development and function

Proceedings of the National Academy of Sciences, Volume 123, Number 5, February 2026.
Significance We recently unveiled a signaling cascade in Drosophila neurons that is activated by an important vertebrate signaling molecule, Reelin. This was rather unexpected since, until recently, Reelin was considered to be a glycoprotein that only…