Dynamic reprogramming of the tumor immune network via multicycle checkpoint degradation for cancer immunotherapy

Proceedings of the National Academy of Sciences, Volume 123, Issue 10, March 2026. <br/>SignificanceImmune checkpoint inhibitors often fail because suppressive checkpoint-linked networks span tumor and myeloid compartments in the tumor immune microenvironment (TIME). We developed Receptormediated Endolysosomal recYcling Chimera (RECYC), a …