Dynamics and variegation in the Treg response to Interleukin-2

Proceedings of the National Academy of Sciences, Volume 122, Number 47, November 2025.
ImportanceInterleukin-2 (IL2) is essential for the maintenance of Treg cells, but how its effects on Treg cells unfold and whether Treg cells are heterogeneous in their responses to IL2 are poorly understood. By analyzing mRNA and chromatin responses to IL2 in…