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The editors of Science are committed to humane and ethical use of animals in research. At a minimum, we require authors to meet the guidelines laid out in the US Animal Welfare Act. We also strongly encourage authors to meet the requirements of European Union Directive 210/63/EU, which is law in the United Kingdom and many European member states. European Union Directive 210/63/EU refers directly to the 3Rs (reduction, replacement, and refinement). These requirements have been posted on our “Science Journal: Editorial policies” page (1) for many years.
