Asparagine endopeptidase prompts breast cancer–related pericardial calcification by regulating IGF2 and integrin αvβ5

Proceedings of the National Academy of Sciences, Volume 122, Issue 49, December 2025. <br/>SignificancePericardial calcification (PC) is frequently observed in breast cancer patients with distant metastasis, especially to the lungs, yet it has largely been overlooked in clinical practice. Our study reveals a significantly positive correlation …