Protein disulfide isomerases regulate androgen receptor stability and promote prostate cancer cell growth and survival

Proceedings of the National Academy of Sciences, Volume 122, Issue 42, October 2025. <br/>SignificanceIn this study, we identified the protein disulfide isomerase (PDI) enzymes PDIA1 and PDIA5 as critical mediators of prostate cancer cell growth and survival. Our research demonstrated that these enzymes have a multifaceted role in prostate …