Engineering a spatiotemporal macrophage circuit via STING phase separation to override immune suppression in pancreatic cancer

Proceedings of the National Academy of Sciences, Volume 122, Issue 47, November 2025. <br/>SignificancePDAC remains one of the deadliest malignancies, with over 80% of patients diagnosed at an advanced or metastatic stage, severely limiting treatment options. Through comprehensive analysis of single-cell RNA sequencing datasets, we identified a …