Enhancing KCC2 function reduces interictal activity and prevents seizures in temporal lobe epilepsy

Proceedings of the National Academy of Sciences, Volume 123, Issue 10, March 2026. <br/>SignificanceA major challenge in treating epilepsy is the high percentage of patients with drug-resistant forms, like mesial temporal lobe epilepsy (mTLE). This study investigates a therapeutic strategy targeting the neuronal KCC2 transporter, which is …