EPOP and MTF2 activate PRC2 activity through DNA-sequence specificity

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Proceedings of the National Academy of Sciences, Volume 123, Number 6, February 2026.
ImportancePolycomb repressive complex 2 (PRC2) silences gene expression by depositing H3K27me3 and is essential for disease development and regulation. How PRC2 activity is initiated at defined genomic sites remains incompletely understood. We identify…

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