Exploring glycoform-dependent dynamic modulations in human immunoglobulin G via computational and experimental approaches

Proceedings of the National Academy of Sciences, Volume 122, Issue 32, August 2025. <br/>SignificanceImmunoglobulin G antibodies rely on their Fc region’s interaction with effector molecules to trigger immune responses. We demonstrate how seemingly subtle variations in Fc glycosylation, specifically galactosylation, profoundly impact Fc …