Fab–Fc and Fab–Fab interactions of variable strength and valency contribute to the high concentration viscosity of IgG1 antibodies

Proceedings of the National Academy of Sciences, Volume 123, Issue 13, March 2026. <br/>SignificanceSubcutaneous injection is increasingly favored over intravenous infusion for antibody therapies such as IgG for multiple reasons including faster administration and greater convenience for patients. Subcutaneous delivery commonly requires …