Dissociation kinetics of G proteins from G protein–coupled receptors and effects of allosteric modulation

Proceedings of the National Academy of Sciences, volume 122, number 46, November 2025.
ImportanceProtein-protein interactions (PPIs) are essential for cell signaling but pose significant challenges for simulations due to their slow dynamics. Dissociation of intracellular proteins from G protein-coupled receptors (GPCRs), main targets of ~1/…