Loss of FoxO in skeletal muscle leads to disrupted muscle metabolism and exacerbates starvation-induced hepatic steatosis

Proceedings of the National Academy of Sciences, Volume 123, Number 15, April 2026.
Significance This study demonstrates that skeletal muscle FoxO transcription factors play an essential role in coordinating systemic lipid homeostasis during starvation. We show that loss of skeletal muscle FoxOs prevents muscle wasting but exacerbates…