CpG-A induces liquid–liquid phase separation of HMGB1 to activate the RAGE-mediated inflammatory pathway

Proceedings of the National Academy of Sciences, Volume 122, number 37, September 2025.
Significantly the release of pathogens and molecular models associated with the danger (PAMPS and DAMP) triggers inflammation and immune responses. Bacterial nucleic acids with non -methyled CPG patterns are common and often present in plasma during infections, …