Formation of a complex between TMEM217 and the sodium-proton exchanger SLC9C1 is crucial for mouse sperm motility and male fertility

Proceedings of the National Academy of Sciences, Volume 122, Number 42, October 2025.
ImportanceAsthenozoospermia, characterized by impaired sperm motility, is a common cause of male infertility. The Na+/H+ exchanger SLC9C1 is an essential regulator of sperm motility through modulation of intracellular signaling. In this study, we…