Forward genetic screening in engineered colorectal cancer organoids identifies regulators of metastasis

Proceedings of the National Academy of Sciences, Volume 122, Issue 46, November 2025. <br/>SignificanceMetastasis is the deadliest, yet least understood step in cancer progression. Here, we developed methodology for uncovering metastasis drivers using in vivo CRISPR/Cas9-based genetic screening in tumor organoid models of colorectal cancer (CRC)…