PIK3CA gain-of-function mutation in Schwann cells leads to severe neuropathy and aerobic glycolysis through a non-cell autonomous effect

Proceedings of the National Academy of Sciences, Volume 122, number 26, July 2025.
Disorders related to the servicephosphatidylinositol-4,5-bisphosphate 3-kinase (PIK3CA) are rare genetic conditions caused by somatic mutations of function gain in the PIK3CA gene, affecting cell growth, proliferation and metabolism. These mutations often …