Gene regulatory logic of the interferon-β enhancer is characterized by two selectively deployed modes of transcription factor synergy

Proceedings of the National Academy of Sciences, Volume 122, Issue 33, August 2025. <br/>SignificancePrecise regulation of the immune cytokine IFNβ is essential for human health. Classic studies established that the transcription factors NFκB and IRF function synergistically in activating IFNβ expression. However, more recent studies revealed …