Genome-wide strand-specific UV mutagenesis in Escherichia coli is directed by the Mfd translocase

Proceedings of the National Academy of Sciences, Volume 122, Issue 46, November 2025. <br/>SignificanceCytotoxic and mutagenic DNA-damaging agents are ubiquitous. Bulky DNA damage is removed genome-wide in bacteria by excision repair, and from transcribed strands (TS) by transcription-coupled repair (TCR), in which the Mfd protein targets …