Mechanistic insights into lenacapavir-induced off-pathway HIV-1 capsid assembly

Proceedings of the National Academy of Sciences, Volume 123, Issue 11, March 2026. <br/>SignificanceOver 40 million people are living with HIV, with approximately one million new infections each year. A defining feature of the virus is its conical capsid consisting of around 1,200 capsid (CA) proteins, which plays key roles across multiple …