Global conformation of the Rag GTPase heterodimer governs eukaryotic amino acid sensing

Proceedings of the National Academy of Sciences, Volume 122, Issue 42, October 2025. <br/>SignificanceThe conformation of a protein—the way its amino acid chain folds into structures—determines how the protein functions and interacts with other molecules. This unique shape dictates the protein’s function, and changes in conformation may alter …