Glycoside hydrolase–mediated glucomannan catabolism in Segatella copri, a target of microbiota-directed foods for malnourished children

Proceedings of the National Academy of Sciences, Volume 122, Number 49, December 2025.
SignificancePreclinical and clinical studies identified candidate bioactive polysaccharides in a microbiota-directed food used to treat acutely malnourished Bangladeshi children during complementary feeding. The discoveries linked to this microbiota-…