Molecular mechanisms underlying p62-dependent secretion of the Alzheimer-associated ubiquitin variant UBB+1

Proceedings of the National Academy of Sciences, Volume 122, Issue 50, December 2025. <br/>SignificanceTo maintain health, cells must remove toxic proteins, typically by ubiquitin-dependent degradation. Neurons are particularly sensitive since they are not dividing and cannot replace damaged cells. This study suggests that autophagy, a pathway …