HES1 oscillations are required for cell cycle reentry in oestrogen receptor–positive breast cancer cells

Proceedings of the National Academy of Sciences, Volume 123, Issue 10, March 2026. <br/>SignificanceBreast cancer can recur years after initial treatment due to reactivation of dormant tumor cells. Understanding how these cells exit dormancy is crucial for preventing relapse. We investigated HES1, a transcription factor with rhythmic protein …