HIF1α mediates circadian regulation of skeletal muscle metabolism and substrate preference in response to time-of-day exercise

Proceedings of the National Academy of Sciences, Volume 122, Issue 28, July 2025. <br/>SignificanceThe timing of exercise influences metabolic outcomes, yet the molecular mechanisms underlying time-of-day-specific adaptations remain unclear. Our study identifies hypoxia-inducible factor-1α (HIF1α) as a key regulator of circadian-dependent …