Notre Dame vs. Pittsburgh odds, line, picks: Week 12 picks from 10,000 simulations

The 10th-ranked Notre Dame Fighting Irish take on the 24th-ranked Pittsburgh Panthers in a key non-conference game Saturday afternoon. Notre Dame is coming off a 49-10 victory over Navy last Saturday, while Pitt beat Stanford 35-20 on November 1. The Fighting Irish (7-2), who have won seven in a row, are 2-1 on the road this season. The Panthers (7-2), who are tied for the Atlantic Coast Conference lead at 5-1, have won five in a row and are 4-1 at home.

Kickoff from Acrisure Stadium in Pittsburgh will be at noon ET. Notre Dame leads the all-time series 51-21-1, including a 28-11-1 lead in games played in Pittsburgh. The Fighting Irish are 12.5-point favorites in the latest Notre Dame vs. Pittsburgh odds, while the over/under in total points scored is 54.5 via the SportsLine consensus. Before making any Notre Dame vs. Pittsburgh picks, check out the college football predictions from the SportsLine Projection Model.

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The model simulates each FBS game 10,000 times. Since its inception, it has generated a betting profit of over $2,000 for $100 players on its top-rated college football picks. Anyone tracking their college football betting picks at sportsbooks and betting sites could have seen some solid returns.

Now, the model has set its sights on Notre Dame vs. Pittsburgh. You can visit SportsLine now to see the picks. Here are the FBS college football odds and trends for Pitt vs. Notre Dame:

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How to make picks for Notre Dame vs. Pittsburgh

The SportsLine model is exceeding the total (54.5). The Over has hit in six of Notre Dame’s last 10 games, while the Over has hit in seven of Pittsburgh’s last 10 games. The model projects Fighting Irish quarterback CJ Carr to throw for over 250 yards and two touchdowns, while running back Jeremiah Love will rush over 15 times for nearly 100 yards and a score.

Panthers quarterback Mason Heintschel is expected to throw for over 200 yards and more than a touchdown. The teams also combine for 58 points while the Over succeeds in more than 50% of simulations.

The model also indicates that one side of the gap hits almost 70% of the time. You can only get this pick at SportsLine.

So who wins Notre Dame against Pittsburgh, and which side of the spread reaches nearly 70% of the time? Visit SportsLine now to see which side of the Notre Dame vs. Pittsburgh spread to jump on, all from the advanced model that has ended up over $2,000 on its FBS college football picks since its inception, and find out.