Phosphatidylinositol 4,5-bisphosphate mediates Arl4D self-interaction to promote Pak1 signaling

Proceedings of the National Academy of Sciences, Volume 123, Number 10, March 2026.
Significance We show how self-association of the small GTPase Arl4D on the membrane is achieved for intracellular signaling that leads to cell migration. This self-association requires the cooperative action of Arl4D binding to a critical lipid, PI(4,5)P2, and…