N6-methyladenosine modification of FZR1 mRNA positively regulates antiviral innate immunity by targeting the MAVS–TRAF3/6 axis

Proceedings of the National Academy of Sciences, Volume 123, Issue 11, March 2026. <br/>SignificanceFizzy-related protein 1 (FZR1) is essential for mitotic exit and G1/S transition, yet its role in antiviral immunity remains poorly characterized. This study reveals that m6A modification of FZR1 mRNA enhances its translation during RNA viral …