HPV16 E6 oncoprotein promotes microhomology-mediated viral integration by increasing PolΘ protein expression

Proceedings of the National Academy of Sciences, Volume 123, Issue 10, March 2026. <br/>SignificanceThe integration of the high-risk human papillomavirus (HPV) genome into host DNA is a critical event in carcinogenesis, yet the underlying mechanisms are not fully understood. This study reveals that the HPV16 E6 oncoprotein actively promotes …