HSCs/MPPs as cells of origin with altered differentiation hierarchy impairing immunomicroenvironment in PML::RARA and CBFα/β fusion AML

Proceedings of the National Academy of Sciences, Volume 123, Issue 6, February 2026. <br/>SignificanceIn many cancers, the immune system and tumor are distinct entities. Our work reveals a unique paradigm in AML where this distinction blurs. Using optimized single-cell technologies across three major AML subtypes, we found that AML-causing …