Human oncogenic herpesvirus latency proteins activate NEK2 to promote chromosomal instability and tumorigenesis

Proceedings of the National Academy of Sciences, Volume 123, Issue 9, March 2026. <br/>SignificanceThis study identifies NEK2 as a critical host kinase hijacked by EBV and KSHV to drive chromosomal instability and uncontrolled proliferation. We show that NEK2 is transcriptionally upregulated by EBNA2 and LANA through RBP-Jκ-dependent …