Hypothalamic endoplasmic reticulum stress drives pubertal precocity due to early-onset obesity in female rodents

Proceedings of the National Academy of Sciences, Volume 123, Number 11, March 2026.
ImportanceChildhood obesity is a worrying disease with increasing prevalence, with adverse health consequences throughout life. Childhood obesity is associated with pubertal disorders; However, the mechanisms by which obesity can disrupt pubertal maturation remain…