Discovery and mechanism of negative allosteric modulation of the α7 nicotinic acetylcholine receptor by nanobodies

Proceedings of the National Academy of Sciences, volume 123, number 4, January 2026.
ImportanceNicotinic acetylcholineα7 receptors are major components of the nervous system. Inhibitors of these ion channels could be used in the treatment of several diseases, including depression and anxiety disorders, but also cancers. To date, only one…