Womb lining test offers miscarriage hope to women

British scientists say they have developed a test that can help identify women with an abnormal factory lining that increases their risk of miscarriage.

They say that their work could open the way for new treatments for those who undergo a repeated loss of pregnancy.

In some women with a history of miscarriage, the lining of the belly does not react as it should – turn into a place of support for the embryo to set up, the team of the University of Warwick discovered.

C charitable organizations say that the results could help provide an explanation, in some cases, for the trauma and devastation of a recurring miscarriage.

About one of the pregnancies in six is ​​lost, most of them before twelve weeks, and each miscarriage increases the risk of another.

To date, most research in this area has focused on the quality of the embryo, with much less on the role of the factory lining.

Dr. Jo Murter, author and researcher of the study at Warwick Medical School, said: “Many women are informed that they have just had” bad luck “, but our results show that the uterus itself may prepare the ground for the loss of pregnancy, even before the design occurs.”

The work of the factory lining is to receive the embryo and help it develop during pregnancy, thanks to a reaction that converts cells into a different support state.

But when this reaction is spoiled and does not occur completely, the risk of bleeding and loss of early pregnancy increases.

Once a woman has had a defective reaction, she is more likely to have another, say the researchers.

They have developed a new test which can measure the signs of a healthy or defective reaction in the factory lining, which is controlled to help more than 1,000 patients at the Tommy’s National Center for Fishriage Research at the University Hospital Coventry & Warwickshire (UHCW).

Charlie Beattie, 37, had countless precocious miscarriages over four years, to the point where “a positive pregnancy test was no longer exciting,” she said.

She and her husband Sam, from Leamington Spa, felt devastated and resigned to consider other options to have a family.

Then they discovered during a test that takes place at the miscarriage research center.

Charlie had a sample of his uterus taken, and the new test showed that he was not “hospital for babies,” she said.

After taking the Sitagliptin medication for three months, she had a pregnancy that finally stuck – and June nine weeks is the joyful result.

“It’s a tiny miracle. It doesn’t seem real,” said Charlie.

She admits to being anxious throughout her pregnancy until June was safe in her arms.

Even pregnancy analyzes have been a new experience.

“We had never seen anything on a scan before,” she said. “When they said:” I can see it, it’s in the right place “, we both have melted in tears.”

Everyone can refer to the clinic, but they have a long waiting list and financing problems mean that patients must contribute to the cost of the test.

Dr. Jyotsna Vohra, director of research at Tommy, said that care and treatment for those who undergo pregnancy or loss of baby varying in an unacceptable way through the United Kingdom.

“There should be no obstacle to access to a test or treatment that has proven to make a difference.

“We hope that NHS decision -makers will carefully examine the results of the Coventry pilot project and consider deploying this test on a national level, so that all those who could benefit have this opportunity.”

Dr. MUTER says that the next step is to use the test to assess potential drug treatments. Sitagliptin, generally used to treat diabetes, is the essential option for problems of lining the uterus, but there may be other existing drugs that can be reused, she added.

With 80% of drugs not tested on pregnant women, we do not know which one could be effective.