Identification of an IRF–ZBP1–caspase-8–NINJ1 axis in driving PANoptosis and pathology during alcohol-associated liver disease

Proceedings of the National Academy of Sciences, Volume 122, Issue 50, December 2025. <br/>SignificanceInnate immunity is essential for host defense, but excess innate immune activation and innate immune cell death can induce a variety of inflammatory diseases, including alcohol-associated liver disease (ALD). ALD is a leading cause of alcohol-…